ARABIDOPSIS
ACYL-LIPID METABOLISM
  ENZYME & PROTEIN DATA
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Ketoacyl-CoA Synthase


malonyl-Coenzyme A CO2
fatty acyl-Coenzyme A (=C18)
Reaction
very long-chain β-ketoacyl-Coenzyme A
Brenda: [2.3.1.119] [2.3.1.120]
IUBMB: [2.3.1.119] [2.3.1.120]
ExPASy: [2.3.1.119] [2.3.1.120]
ExplorEnz: [2.3.1.119] [2.3.1.120]
PDB: [2.3.1.119] [2.3.1.120]

 

Enzyme Pathways

FA Elong & Wax | Suberin I

Locus Data & Links    (May need to scroll right or left to show columns)

Locus Id
(TAIR Link)
Abbrev. Mutant(s)
(click for pop-up)
Pathway(s) Subcelluar
location
Evidence for
function
Key
References
Comments Microarray
Expression
Proteomics
data
ESTexpression
in other oilseeds
KCS1
Endomembrane
Mutant Char.; Heterol Exp'n.
4 Refs
Chainlength specific reduction in waxes; increase in esterified diacids in roots; recombinant protein can act in elongation complexes producing C18-C22 fatty acids
Efp Eth Data
KCS2 / DAISY
Endomembrane
Endomembrane (GFP)
Mutant Char.; Heterol Exp'n.; Comple. of yeast mutant
9 Refs
Protein family of 21 members-Root but not seed suberin phenotype. Other family members may have redundant functions. Double mutant of kcs2,kcs20 results in 15-20% reduction in cuticular wax. STKCS6 homology to both AtKCS6 and AtKCS5 is similar; it cannot unambiguously be assumed that StKCS6 is the potato orthologue of AtKCS6.
Efp Eth Data
KCS3
Endomembrane
1 Ref
Upregulated in epidermis of stems
Efp Eth Data
KCS4
Endomembrane
Mutant Char.
1 Ref
Preferentially root expressed; protein family of 21 members; other family members may have redundant functions.
Efp Eth Data
KCS5 / CER60
Endomembrane
Mutant Char.; Heterol Exp'n.; potato StKCS6-RNAi characterization; seq. similarity to AtKSC5
5 Refs
STKCS6 homology to both AtKCS6 and AtKCS5 is similar; it cannot unambiguously be assumed that StKCS6 is the potato orthologue of AtKCS5; Upregulated in epidermis of stems;
Efp Eth Data
KCS6 / CER6 / CUT1
Endomembrane
Mutant Char.
Potato StKCS6-RNAi characterization; Arabidopsis mutant analysis (wax phenotype)
3 Refs
Protein family of 21 members-Root but not seed suberin phenotype. Other family members may have redundant functions. Double mutant of kcs2,kcs20 results in 15-20% reduction in cuticular wax. STKCS6 homology to both AtKCS6 and AtKCS5 is similar; it cannot unambiguously be assumed that StKCS6 is the potato orthologue of AtKCS6.
,Cuticular wax and fertility defect in mutants due to loss of pollen coat lipids.
Efp Eth Data
KCS7
Endomembrane
Efp Eth Data
KCS8
Endomembrane
Efp Eth Data
KCS9
Endomembrane
Mutant Char.; Comple. of yeast mutant
3 Refs
Highly expressed ; upregulated in epidermis of stems;
Efp Eth Data
KCS10 / FDH
Endomembrane (proteomics)
Mutant Char.
2 Refs
Possible that FDH not directly involved in cuticular wax biosynthesis
Efp Eth Data
KCS11
Endomembrane
Efp Eth Data
KCS12
Endomembrane
1 Ref
Upregulated in epidermis of stems
Efp Eth Data
KCS13 / HIC
Endomembrane
Mutant Char.
1 Ref
Involved in control of stomate numbers at high CO2 concentrations; no evidence of role in cuticular wax biosynthesis
Efp Eth Data
KCS14
Endomembrane
Efp Eth Data
KCS15
Endomembrane
Efp Eth Data
KCS16
Endomembrane
Efp Eth Data
KCS17
Endomembrane
Mutant Char.; Heterol Exp'n.
2 Refs
No indication of role in cuticular wax biosynthesis
Efp Eth Data
KCS18 / FAE1
Endomembrane
Mutant Char.; Heterol Exp'n.
4 Refs
Seed-specific KCS; no role in cuticular wax production
Efp Eth Data
KCS19
Endomembrane
Efp Eth Data
KCS20
Endomembrane
Mutant Char.; Heterol Exp'n.; Comple. of yeast mutant
3 Refs
Double mutant of kcs2 kcs20 results in 15-20% reduction in cuticular wax; also a suberin-associated KCS; Highly expressed ; upregulated in epidermis of stems; reduced suberin monomers in kcs2 and kcs20 double mutant
Efp Eth Data
KCS21
Endomembrane
Efp Eth
extracellular cuticle-localized
Mutant Char.; Heterol Exp'n.; Comple. of yeast mutant
2 Refs
Function shown in tomato cutin assembly.