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Legend: (A) Examples of the involvement of auxiliary activities in the degradation of oleic acid (C18:1Δ9cis). (B) The core b-oxidation cycle. (C) Example of the involvement of the monofunctional type 2 enoyl-CoA hydratase (ECH2) in the degradation of fatty acids with a cis double bond on an even-numbered carbon (C18:1Δ6cis, petroselinic acid). Triacylglycerols are first degraded by cellular lipases to relases free fatty acids from glycerol. Then reactions involved in the β-oxidation of straight chain fatty acids in the peroxisome (adopted from Goepfert and Poirier 2007). â2x cyclesâ indicates that the molecule undergoes two successive rounds through the β-oxidation cycle. CTS is an ABC transporter involved in the import of β-oxidation substrates to the peroxisome. Abbreviations: ACT, acyl-CoA thioesterase; ACX, acyl-CoA oxidase; DCI1, D3,5,D2,4-dienoyl-CoA isomerase; Isom, D3,D2-enoyl-CoA isomerase; KAT, 3-ketothiolase; LACS, long chain acyl-CoA synthetase; MFP, multifunctional protein containing a 2trans-enoyl-CoA hydratase (ECH) and a 3S-hydroxyacyl-CoA dehydrogenase (HACDH); Red, 2,4-dienoyl-CoA reductase; TAGL, triacylglycerol lipase; MFP represents only the 2E-enoyl-CoA hydratase activity of the multifunctional protein.