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Coenzyme A |
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acetyl-Coenzyme A |
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3-ketoacyl-Coenzyme A |
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acyl-Coenzyme A |
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Locus Data & Links (May need to scroll right or left to show columns)
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KAT1
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Peroxisome
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Seq. Similarity
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Data
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KAT2 / PED1
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Peroxisome
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Mutant Char.; Heterol Exp'n.
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3 Refs
Germain, V., Rylott, E.L., Larson, T.R., Sherson, S.M., Bechtold, N., Carde, J.P., Bryce, J.H., Graham, I.A., and Smith, S.M. (2001). Requirement for 3-ketoacyl-CoA thiolase-2 in peroxisome development, fatty acid beta-oxidation and breakdown of triacylglycerol in lipid bodies of Arabidopsis seedlings. Plant J. 28 , 1-12.Jiang, T., Zhang, X.F., Wang, X.F., and Zhang, D.P. (2011). Arabidopsis 3-Ketoacyl-CoA Thiolase-2 (KAT2), an Enzyme of Fatty Acid beta-Oxidation, is Involved in ABA Signal Transduction. Plant and Cell Physiology 52 , 528-538.Hayashi, M., Toriyama, K., Kondo, M., and Nishimura, M. (1998). 2,4-dichlorophenoxybutyric acid-resistant mutants of Arabidopsis have defects in glyoxysomal fatty acid beta-oxidation. Plant Cell 10 , 183-195.
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This is the main thiolase that can be linked to the to the prt B scheme in the b-ox figure.
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Data
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PKT1
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Peroxisome
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in-planta Overexp'n.
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2 Refs
Germain, V., Rylott, E.L., Larson, T.R., Sherson, S.M., Bechtold, N., Carde, J.P., Bryce, J.H., Graham, I.A., and Smith, S.M. (2001). Requirement for 3-ketoacyl-CoA thiolase-2 in peroxisome development, fatty acid beta-oxidation and breakdown of triacylglycerol in lipid bodies of Arabidopsis seedlings. Plant J. 28 , 1-12.Carrie, C., Murcha, M.W., Millar, A.H., Smith, S.M., and Whelan, J. (2007). Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are targeted either to peroxisomes or cytosol but not to mitochondria. Plant Mol. Biol. 63 , 97-108.
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The KAT5 cDNA complements the kat2 mutant (Germian et al., 2001). KAT5 produces two polypeptides, KAT5.1 and KAT5.2, apparently as a consequence of alternate RNA splicing - KAT5.1 appears to be cytosolic while KAT5.2 is peroxisomal (Carrie et al., 2007).
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Data
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