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Acetyl-CoA Carboxylase (multisubunits)
(
Heteromeric
)
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Biotin Carboxylase; subunit of Heteromeric ACCase
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| ATP+HCO3- |
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ADP+ phosphate |
| biotin-carboxyl-carrier protein |
|
carboxybiotin-carboxyl-carrier protein |
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Carboxyltransferase alpha Subunit of Heteromeric ACCase
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| a carboxylated-biotinylated-BCCP |
|
a biotinylated-BCCP |
| acetyl-CoA |
|
malonyl-CoA |
|
Carboxyltransferase beta Subunit of Heteromeric ACCase
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| a carboxylated-biotinylated-BCCP |
|
a biotinylated-BCCP |
| acetyl-CoA |
|
malonyl-CoA |
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Locus Data & Links (May need to scroll right or left to show columns)
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α-CT
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Fatty Acid Synth
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Plastid
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Seq. Similarity
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2 Refs
Bilder, P., Lightle, S., Bainbridge, G., Ohren, J., Finzel, B., Sun, F., Holley, S., Al-Kassim, L., Spessard, C., Melnick, M., Newcomer, M., and Waldrop, G.L. (2006). The structure of the carboxyltransferase component of acetyl-CoA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme. Biochemistry 45 , 1712-1722.Reverdatto, S., Beilinson, V., and Nielsen, N.C. (1999). A multisubunit acetyl coenzyme A carboxylase from soybean. Plant Physiology 119 , 961-978.
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Seq. Similarity to E. coli α-CT
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Data
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BCCP2
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Fatty Acid Synth
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Plastid
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Mutant Char.
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4 Refs
Thelen, J.J., and Ohlrogge, J.B. (2002). Both antisense and sense expression of biotin carboxyl carrier protein isoform 2 inactivates the plastid acetyl?coenzyme A carboxylase in Arabidopsis thaliana. The Plant Journal 32 , 419-431.Li, X., Ilarslan, H., Brachova, L., Qian, H.R., Li, L., Che, P., Wurtele, E.S., and Nikolau, B.J. (2011). Reverse-Genetic Analysis of the Two Biotin-Containing Subunit Genes of the Heteromeric Acetyl-Coenzyme A Carboxylase in Arabidopsis Indicates a Unidirectional Functional Redundancy. Plant Physiology 155 ,293-314.Chen, M.J., Mooney, B.P., Hajduch, M., Joshi, T., Zhou, M.Y., Xu, D., and Thelen, J.J. (2009). System Analysis of an Arabidopsis Mutant Altered in de Novo Fatty Acid Synthesis Reveals Diverse Changes in Seed Composition and Metabolism. Plant Physiology 150 , 27-41.Reverdatto, S., Beilinson, V., and Nielsen, N.C. (1999). A multisubunit acetyl coenzyme A carboxylase from soybean. Plant Physiology 119 , 961-978.
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Seq. Similarity to soybean BC; lipid phenotype not observed
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Data
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BCCP1
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Fatty Acid Synth
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Plastid
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Heterol Exp'n.; Seq. Similarity
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3 Refs
Li, X., Ilarslan, H., Brachova, L., Qian, H.R., Li, L., Che, P., Wurtele, E.S., and Nikolau, B.J. (2011). Reverse-Genetic Analysis of the Two Biotin-Containing Subunit Genes of the Heteromeric Acetyl-Coenzyme A Carboxylase in Arabidopsis Indicates a Unidirectional Functional Redundancy. Plant Physiology 155 ,293-314.Choi, J.K., Yu, F., Wurtele, E.S., and Nikolau, B.J. (1995). MOLECULAR-CLONING AND CHARACTERIZATION OF THE CDNA CODING FOR THE BIOTIN-CONTAINING SUBUNIT OF THE CHLOROPLASTIC ACETYL-COENZYME-A CARBOXYLASE. Plant Physiology 109 , 619-625.Reverdatto, S., Beilinson, V., and Nielsen, N.C. (1999). A multisubunit acetyl coenzyme A carboxylase from soybean. Plant Physiology 119 , 961-978.
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Seq. Similarity to soybean BC
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Data
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BC
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Fatty Acid Synth
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Plastid
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Heterol Exp'n.; Seq. Similarity
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2 Refs
Sun, J.D., Ke, J.S., Johnson, J.L., Nikolau, B.J., and Wurtele, E.S. (1997). Biochemical and molecular biological characterization of CAC2, the Arabidopsis thaliana gene coding for the biotin carboxylase subunit of the plastidic acetyl-coenzyme A carboxylase. Plant Physiology 115 , 1371-1383.Reverdatto, S., Beilinson, V., and Nielsen, N.C. (1999). A multisubunit acetyl coenzyme A carboxylase from soybean. Plant Physiology 119 , 961-978.
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Seq. Similarity to soybean BC
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Data
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β-CT (accD)
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Fatty Acid Synth
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Plastid
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Seq. Similarity
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1 Ref
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Seq. Similarity to E. coli ?-CT
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Data
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