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Serine Palmitoyltransferase
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Heteromeric
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Long-Chain Base 2
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| serine |
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CoA + CO2 |
| palmitoyl-CoA |
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3-ketosphinganine |
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Long-Chain Base 1
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| serine |
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CoA + CO2 |
| palmitoyl-CoA |
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3-ketosphinganine |
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Locus Data & Links (May need to scroll right or left to show columns)
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ssSPTa
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Sphingolipid I
Sphingolipid II
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Mutant Char.; Heterol Exp'n.; in vitro assays
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1 Ref
Kimberlin, A.N., Majumder, S., Han, G.S., Chen, M., Cahoon, R.E., Stone, J.M., Dunn, T.M., and Cahoon, E.B. (2013). Arabidopsis 56-Amino Acid Serine Palmitoyltransferase-Interacting Proteins Stimulate Sphingolipid Synthesis, Are Essential, and Affect Mycotoxin Sensitivity. Plant Cell 25 ,4627-4639.
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essential for male gametophytes, are important for FB1 sensitivity, and limit sphingolipid synthesis in planta.
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Data
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ssSPTb
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Sphingolipid I
Sphingolipid II
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Mutant Char.; Heterol Exp'n.; in vitro assays
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2 Refs
Kimberlin, A.N., Majumder, S., Han, G.S., Chen, M., Cahoon, R.E., Stone, J.M., Dunn, T.M., and Cahoon, E.B. (2013). Arabidopsis 56-Amino Acid Serine Palmitoyltransferase-Interacting Proteins Stimulate Sphingolipid Synthesis, Are Essential, and Affect Mycotoxin Sensitivity. Plant Cell 25 ,4627-4639.Smith, M.A., Dauk, M., Ramadan, H., Yang, H., Seamons, L.E., Haslam, R.P., Beaudoin, F., Ramirez-Erosa, I., and Forseille, L. (2013). Involvement of Arabidopsis ACYL-COENZYME A DESATURASE-LIKE2 (At2g31360) in the Biosynthesis of the Very-Long-Chain Monounsaturated Fatty Acid Components of Membrane Lipids. Plant Physiology 161 ,81-96.
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essential for male gametophytes, are important for FB1 sensitivity, and limit sphingolipid synthesis in planta.
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Data
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LCB2b
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Sphingolipid I
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Endomembrane (GFP)
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Heterol Exp'n.
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2 Refs
Teng, C., Dong, H., Shi, L., Deng, Y., Mu, J., Zhang, J., Yang, X., and Zuo, J. (2008). Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in Arabidopsis. Plant Physiology 146 , 1322-1332.Dietrich, C.R., Han, G., Chen, M., Berg, R.H., Dunn, T.M., and Cahoon, E.B. (2008). Loss-of-function mutations and inducible RNAi suppression of Arabidopsis LCB2 genes reveal the critical role of sphingolipids in gametophytic and sporophytic cell viability. Plant J. 54 , 284-298.
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Data
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LCB1
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Sphingolipid I
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Endomembrame (GFP-fusion) Endomembrane (proteomics)
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Mutant Char.; Heterol Exp'n.
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2 Refs
Teng, C., Dong, H., Shi, L., Deng, Y., Mu, J., Zhang, J., Yang, X., and Zuo, J. (2008). Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in Arabidopsis. Plant Physiology 146 , 1322-1332.Chen, M., Han, G.S., Dietrich, C.R., Dunn, T.M., and Cahoon, E.B. (2006). The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase. Plant Cell 18 , 3576-3593.
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Data
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LCB2a
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Sphingolipid I
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Endomembrane (GFP)Vacuole (proteomics)
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Heterol Exp'n.
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2 Refs
Teng, C., Dong, H., Shi, L., Deng, Y., Mu, J., Zhang, J., Yang, X., and Zuo, J. (2008). Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in Arabidopsis. Plant Physiology 146 , 1322-1332.Dietrich, C.R., Han, G., Chen, M., Berg, R.H., Dunn, T.M., and Cahoon, E.B. (2008). Loss-of-function mutations and inducible RNAi suppression of Arabidopsis LCB2 genes reveal the critical role of sphingolipids in gametophytic and sporophytic cell viability. Plant J. 54 , 284-298.
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Data
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