ARABIDOPSIS
ACYL-LIPID METABOLISM
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Glycerol-3-Phosphate Acyltransferase


acyl-CoA
acyl-ACP(plastid)
CoA
ACP(plastid)
glycerol-3-phosphate
Reaction
1-acylglycerol-3-phosphate
Brenda: [2.3.1.198] [2.3.1.15]
IUBMB: [2.3.1.198] [2.3.1.15]
ExPASy: [2.3.1.198] [2.3.1.15]
ExplorEnz: [2.3.1.198] [2.3.1.15]
PDB: [2.3.1.198] [2.3.1.15]

 
Comments: sn-1-GPAT: Commonly known as GPAT. Membrane and storage lipids. Plastid, soluble. ER, other membranes?

acyl-CoA CoA
glycerol-3-phosphate
Reaction
2-acylglycerol-3-phosphate (suberin)
2-monoacylglycerol (cutin)
Brenda: [2.3.1.198] [2.3.1.15]
IUBMB: [2.3.1.198] [2.3.1.15]
ExPASy: [2.3.1.198] [2.3.1.15]
ExplorEnz: [2.3.1.198] [2.3.1.15]
PDB: [2.3.1.198] [2.3.1.15]

 
Comments: sn-2-GPAT: Cutin and Suberin Pathways

Enzyme Pathways

Prok Gal/Sulpho I | TAG Synthesis | Euk Phospholipid | Mito Phospholipid | Cutin I | Suberin I

Locus Data & Links    (May need to scroll right or left to show columns)

Locus Id
(TAIR Link)
Abbrev. Mutant(s)
(click for pop-up)
Pathway(s) Subcelluar
location
Evidence for
function
Key
References
Comments Microarray
Expression
Proteomics
data
ESTexpression
in other oilseeds
sn-2-GPAT4
Plasma / ER?
Mutant Char.; Phosphatase activity in vitro detected in plasma membrane proteomics
4 Refs
Acyl acceptor could be glycerol-3-phosphate or glycerol. Has also phosphatase activity in vitro
Efp Eth Data
GPAT2
Mitochondria
Mutant Char.; Seq. Similarity
2 Refs
No in vitro activity detected
Efp Eth Data
sn-2-GPAT1
Mitochondria (in vitro import and western blot on subcellular fractions) and Endomembrane
Mutant Char.; Heterol Exp'n.
2 Refs
Has in vitro sn-2 acyltransferase but no phosphatase activity. Not only in mitochondria but also in endomembranes. Fertility phenotype in mutant. GPAT1, an isozyme with uncertain function but for tapetum and anther development (Zheng et al., 2003; Li et al., 2012)
Efp Eth Data
ATS1 / ACT1
Plastid
Mutant Char.; Heterol Exp'n.
3 Refs
Originally isolated point mutants are leaky, allowing synthesis of PG through the prokaryotic pathway, whereas TDNA insertion loss of function mutations are embryo lethal
Efp Eth Data
sn-2-GPAT6
Plasma / ER?
Mutant Char.; Heterol Exp'n.; in-planta Overexp'n.
5 Refs
Has also phosphatase activity in vitro
Efp Eth Data
sn-2-GPAT5
Endoplasmic reticulum?
Mutant Char.; Heterol Exp'n.; in-planta Overexp'n.
3 Refs
Mutant deficient in suberin aliphatic monomers. Increased sensitivity to salt. Increased seed coat permeability.
Efp Eth Data
sn-2-GPAT8
Plasma / ER?
Mutant Char.; Heterol Exp'n.; in-planta Overexp'n.
5 Refs
Has also phosphatase activity in vitro
Efp Eth Data
GPAT3
Mitochondria
Mutant Char.; Seq. Similarity
2 Refs
No in vitro activity detected
Efp Eth Data
sn-2-GPAT7
Endoplasmic reticulum?
Mutant Char.; Seq. Similarity
2 Refs
Efp Eth
GPAT9? (mammalian homologue)
Endomembrane
Seq. Similarity
2 Refs
Seq. Similarity to mammalian ER localised GPAT
Efp Eth Data